BRI
Biophillic Research Institute
Autoimmune Antibodies Stack
Autoimmune diseases may originate from antigen processing failures in Dendritic Cells that essentially pollute immune memory.
Resolution requires eliminating these memory cells while actively encouraging the regeneration of fresh ones.
Septic Infection Immune System Stack
The Thymus organ influences T cell production by creating peptides in concert. T cells may become exhausted if their mitochondria weaken.
T cells with strong mitochondria may reduce immune exhaustion. Strong T cells kill more cells, requiring efferocytosis.
Acidic Warburg Effect Cancer Stack
Otto Warburg, a Nobel laureate, demonstrated how many types of cancers consume glucose instead of oxygen, producing lactic acid as a byproduct.
This is known as the Warburg Effect. phLIP peptides (paired with cytotoxic payloads) are attracted to this acidity.
Chronic Inflammatory Senescence Stack
Studies report that senescent cells may release 150 times more inflammation than normal cells in order to attract immune cells to kill the senescent cells.
Cancer relapse or risk may rise when senescent cells accumulate if SASP outpace immune cell recruitment.
Atherosclerosis and Microplastics Stack
Microplastics, fatty plaques, trans fats, ApoB, and more are increasing the burden of scavenging lipid cores by phagocytotic macrophages.
Macrophage TNTs extract lipid cores through the plaque cap, then the RCT cycle binds it to HDL for excretion via TICE.
Combining Stacks in Mouse Trials
In normal life, most people accumulate diseases simultaneously. For example, senescence after cancer and atherosclerosis after infections.
These mouse trials will combine stacks in mice with these comorbidities to stress-test the stacks in concert.
Global Cost Burden
The Population of America Dies Each Decade
100T+ Dollars
Estimated Cost Of Antibiotic Resistance By Year 2150
150M+ People
Deaths Per Decade From
Sepsis and Infections
20T+ Dollars
Cost Of COVID-19 Pandemic
On Global Economy
200M+ People
Deaths Per Decade From
Plaques and Heart Disease
Open-Source Publications
All data is entirely open-source and the team is passionately dedicated to advancing this research for personal reasons beyond recognition or profit.
Non-Profit Coalition
All funds are allocated to the Biophilic institute to be utilized exclusively for trials and operating costs.
We design protocols and new peptides that can be trialed and studied. Many types of medical products may emerge from our research.
